Ointment bases pdf download

Ep0037011a3 ointment bases for dermatological and cosmetic. Introduction herbal drugs are formulated in the form of ointment and are used topically for several purposes, e. Ointment bases pdf ointment bases pdf ointment bases pdf download. On the type by character of ointment bases distinguish ointments, prepared on. We find ourselves in general agreement with opinions he has expressed. The water soluble ointment bases showed some beneficial effects, whereas oily bases made the skin lesions worse. Each therapeutic ointment possesses as its base one of these four general classes. Each therapeutic ointment possesses as its base a representative of one of these four general classes. The ointment base needs to be heated to above its melting temperature prior to the addition of the other ingredients.

Overall result of this study reveals that this is an effective. A flowchart was designed to help students select the appropriate base for an ointment. Preparation of ointment bases university of north carolina. Ointment base excipients inert pharmaceutical ingredients. Ointments and creams are the semisolid dosage forms and intended for topical application to the skin, placed on the surface of eye, or used nasally, vaginally or rectally for therapeutic or protective action or cosmetic function. There exist two schools of thought regarding the preparation of ointments by fusion. A comparative study of the use of hydrophilic absorption ointment. Spectrum specializes in providing the top ointment base excipients but if you do not see the product, grade or form of the ingredient you require, just contact our chemical specialist at 8007728786. There are five 5 classes or types of ointment bases which are differentiated on the basis of their physical composition. Influence of drug concentration on in vitro release of. Lowshear or mixing speeds are typically used when the ointment base or finished formulation is coldthick.

The topicaltransdermal ad hoc advisory panel for the usp. Topical base an anhydrous, nonocclusive, lipidfree ointment base. Our range of solubilizers and penetration enhancers support effective delivery of the target api the numberone priority when designing any dermatological. They may be diluted with water or aqueous solutions e. Ointment bases are always anhydrous and generally contain one or more. Release of sorbic acid from ointment bases sciencedirect. The purpose of this research was to evaluate different parameters that can influence in vitro drug release from topical dermatological drug products such as creams, gels, and ointments.

Although emulsifying wax is compatible with many acids and alkalis, it is incompatible with many cationic materials and polyvalent metal salts. Each ointment base type has different physical characteristics and therapeutic uses based upon the nature of its components. Traditionally, authorities in the pharmaceutical field have general directed that the high melting point ingredients be melted first and the remaining ingredients added in order of their decreasing melting points so that the lower melting ingredients are not subjected to the temperatures. Formulation design of ointment base suitable for healing of. In an attempt to answer some of these questions, a series of patch tests has been performed with many of the commonly used ointment bases, the compositions of. Download as ppt, pdf, txt or read online from scribd. Chief pharmacist, hawkes bay hospital board, napier, new zealand. High molecular weight polyethylene glycols, such as peg 1450 kollisolv peg 1450, peg 3350 kollisolv peg 3350 and higher, can form networks or microstructures that increase the viscosity of the hydrophilic ointment base thereby improving ointment stability and also allowing the user to effectively transfer the product from the primary package to the location of application. We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. The effect of cream and ointment bases on the steady state. The effect of drug concentration on in vitro release of salicylic acid from a series of ointment bases was investigated. Castroviejo has commented in a very intelligent and practical way on the paper, ophthalmic ointment bases in the anterior chamber, by scheie, rubenstein, and katowitz.

Influence of ointment base composition on the release of sorbic acid from ointments containing 2% ww drug. It is watersoluble, waterwashable, and can absorb water. Experimental studies on the penetration of the following substances. Make sure that you follow closely the procedures for preparation. Homogeneous ointments free download as powerpoint presentation. As a current student on this bumpy collegiate pathway, i stumbled upon course hero, where i can find study resources for. Types of ointment bases hydrocarbon bases absorption bases nonemulsified bases water. Pdf properties of ointment bases monica may lopez academia. The bases were commercially available vehicles containing lanolin and or lanolin derivatives and formed stable water.

Types of base for ointments and pastes there are four types of base that are used to formulate pharmaceutical ointments and pastes. A modified screw design was used in this process, and parameters such as feeding rate, barrel temperature, and screw speed were. In light of the high drug content, this point is particularly important in the formulation of pastes. Ointment base was prepared and formulation of ointment was done by. View enhanced pdf access article on wiley online library html view download pdf for offline viewing. An evaluation of methods for compounding fused ointment. Comparative study of ointment bases jama dermatology. Ointment base definition of ointment base by medical dictionary. Basf offers an extensive portfolio of excipients for topical formulations enabling you to create the ideal skin delivery solution for ointment formulation. The following table summarizes the composition, properties, and common uses of each of the five types. To characterize cream or ointment bases for cosmetic or pharmaceutical purposes with regard to their effect on permeant penetration through intact healthy skin, the measurement of the pharmacodynamic response of a suitable model drug incorporated in these bases has been shown to be a promising approach. Hydrocarbon bases hydrocarbon bases, known also as oleaginous ointment bases, are represented by white petrolatum and white ointment both usp. Hence an attempt was made to formulate a polyherbal ointment, and to evaluate for its physical parameter, invitro antioxidant activity and to compare its antibacterial activity with a marketed formulation 5% ww betadine.

The purpose of this chapter is to give you basic knowledge about ointment bases and their ingredi. Properties of ointment bases types of ointment oleaginous absorption ointment water in oil emulsion oil in water emulsion. The ointment formulation was designed by using five different ointment bases. Oct 23, 2016 the ointment is applied as a narrow band of approximately 0. Pdf development and evaluation of polyherbal ointments for. Ep07212a2 ep84109563a ep84109563a ep07212a2 ep 07212 a2 ep07212 a2 ep 07212a2 ep 84109563 a ep84109563 a ep 84109563a ep 84109563 a ep84109563 a ep 84109563a ep 07212 a2 ep07212 a2 ep 07212a2 authority ep european patent office prior art keywords ointment weight formula ointment base defined prior art date 19830812. At the end of the semester, students completed a dry laboratory practical that required them to select an appropriate ointment base and levigating agent. Students used the flowchart throughout the semester in both dry and wet laboratory activities. We are committed to maintaining the highest level of quality.

Ointments and creams by sajjad lcps 03006389123 authorstream. Ten years ago there were but a few simple ointments a. Comparative study of ointment bases jama dermatology jama. The current study proposes the use of hotmelt extrusion hme processing for the preparation of a polyethylene glycol base ointment. In our hospital, a simple lipophilic ointment base, in which antibiotics.

Because the external phase of the emulsion is aqueous, they are easily washed from skin and are often called water washable bases. Most oils mix easily with hydrocarbon bases, but they reduce the viscosity of the preparation. Rectal ointments these are the ointments to be applied to the peri anal or within the anal canal. Homogeneous ointments topical medication solubility. Capacity of various ointment bases to absorb solvents. Typical ointment bases comprise petrolatum and mineral oil, or petrolatum and waxyfatty alcohol combinations, the ratio. Ointment bases recognized for use as vehicles fall into four general classes.

They are also described as waterwashable, since they may be readily washed from the skin or clothing with water, an attribute that makes them more acceptable for cosmetic reasons. The ointment is applied as a narrow band of approximately 0. Find, read and cite all the research you need on researchgate. The subject of ointment bases is one that lias increased considerably in complexity over the years.

Is the ointment base or one of the materials added to the base responsible for the irritation. Prepare 120 g of each of the following five ointments on a ww basis. Tailormade advice and recommended formulations give many pharmacies and pharmaceuticalcosmetic manufacturers security in formulating premium products. Take a quantity of the preparation shake the container gently if necessary corresponding to at least 10. The bases used are combinations of peg 300 and peg 3350, cetyl alcohol and cetyl esters, wax, liquid paraffin and white paraffin. Oleaginous base white ointment absorption base hydrophilic petrolatum white wax 5% cholesterol 3% white petrolatum 95% stearyl alcohol 3% white wax. Learn vocabulary, terms, and more with flashcards, games, and other study tools. A new ointment base consisting essentially of saturated hydrocarbons is reported. Feb 12, 2014 a flowchart was designed to help students select the appropriate base for an ointment. The selection of an ointment base in which drugs are to be incorporated for local application should depend on the condition of the patients skin, the biological effect desired, and the pharmaceutical compatibility of the ingredients with each other and the base. Ointment bases are prepared by mixing up to 50% emulsifying wax with liquid or soft paraffi ns.

They are usually prepared from nonaqueous bases, e. Development of an ointment formulation using hotmelt. Ointment base definition of ointment base by medical. In the chemical processes of the body, bases are essential to the maintenance of a normal acidbase balance. Ointment bases, australasian journal of dermatology 10.

Medisca provides compounding pharmacies with diverse line of qualityassured bases such as gels, creams, ointments and oral vehicles. This base, jelene 50w, has been substituted for the bases of official ointments and the new and t h e official preparations have been studied under various conditions. Procedure master listing non covered apisexcipients. Pdf development and evaluation of polyherbal ointments. Mar 26, 2017 3 waterremovable bases waterremovable bases are oilinwater emulsions resembling creams in appearance.

The superiority of the emulsifying bases is rather well known and both the water inoil and the oilinwater emulsions have established their places in. Particle size ophthalmic preparations containing dispersed solid particles comply with the following test. Based on their makeup, ointment bases have varying capacities to absorb liquids. Prior art keywords dermatological cosmetic use ointment bases ointment bases prior art date 19800319 legal status the legal status is an assumption and is not a legal conclusion. It has high stability over a wide range of temperature. In vitro bioequivalence data for a topical product. Formulation and evaluation of antiseptic polyherbal ointment.

Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed. Only small amounts of an aqueous component can be incorporated into these bases. Hydrocarbon baseshydrocarbon bases, known also as oleaginous ointment bases, are. Thank you for your interest in spreading the word about the bmj. The architectural waterproof asphalt jointing ointment is an ointment material which is based on asphalt and blended with modifier such as waste rubber powder and sulfide fish oil, diluents such as pine tar, pine knot heavy oil and engine oil and fillers such as asbestos wool and. Ointments are generally prepared either by fusion or by levigation methods.